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| HUANG Haihong,ZHENG Minghui,SU Shenghui.Positive rate of bacterial culture of X-ray fluoroscopy-guided percutaneous biopsy in primary spinal infections and influencing factors[J].Chinese Journal of Spine and Spinal Cord,2022,(10):930-937. |
| Positive rate of bacterial culture of X-ray fluoroscopy-guided percutaneous biopsy in primary spinal infections and influencing factors |
| Received:June 18, 2022 Revised:September 28, 2022 |
| English Keywords:Spinal infections Percutaneous biopsy Positive rate Influencing factors |
| Fund:南方医科大学南方医院脊柱感染亚专科建设项目（编号：J101018029） |
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| English Abstract: |
| 【Abstract】 Objectives: To calculate the positive bacterial culture rate of X-ray fluoroscopy-guided percutaneous biopsy in primary spinal infections and analyze the factors influencing the positive cultures. Methods: A total of 179 patients with primary spinal infections who underwent fluoroscopy-guided percutaneous biopsy in the Division of Spine Surgery of Nanfang Hospital and Orthopedics Department of Nanfang Hospital Zengcheng Branch from August 2018 to August 2021 were retrospectively reviewed, including 110 males and 69 females, aged 54.63±13.70 years old. Cases were divided into culture-positive group(n=100) and culture-negative group(n=79) based on culture results. The culture positive rate was calculated, and the factors including demographics, antibiotics intervention, clinical manifestation, laboratory examination, imaging data, biopsy procedure, blood culture, and histopathology examination were analyzed to determine the culture positive-related influencing facors by Logistic regression analysis. Results: The culture positive rate of biopsy was 56%. A total of 119 strains of 36 species of microorganisms were cultured from 100 puncture culture positive specimens, among which 81 strains(81%) were single microorganisms. The common microorganisms were Mycobacterium tuberculosis(n=24), Staphylococcus epidermis(n=16), Staphylococcus aureus(n=12), Escherichia coli(n=8), and Brucella(n=8). Logistic regression analysis showed that the level of CRP, biopsy site, biopsy level had no effect on the positive results of biopsy culture, while hypertension(OR 0.139, 95%CI: 0.038-0.500, P=0.003), antibiotics intervention(OR 0.221, 95%CI: 0.063-0.784, P=0.019), and paravertebral abscess(OR 8.495, 95%CI:1.623-44.479, P=0.011) were the influencing factors for positive biopsy cultures. Conclusions: The overall positive bacterial culture rate of fluoroscopy-guided percutaneous puncture biopsy in primary spinal infections is 56%, and hypertension, antibiotics intervention, and paravertebral abscess are the factors influencing the biopsy culture results. |
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