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| DAI Zhehao,Lv Guohua,WANG Bing.Scoliosis model in an asymmetric force bipedal rat and bone micro-architecture adaptations of ver?鄄tebrae[J].Chinese Journal of Spine and Spinal Cord,2015,(3):259-286. |
| Scoliosis model in an asymmetric force bipedal rat and bone micro-architecture adaptations of ver?鄄tebrae |
| Received:January 04, 2015 Revised:March 11, 2015 |
| English Keywords:Scoliosis Bipedal rat Asymmetric load Bone micro-architecture |
| Fund:国家自然科学基金项目（编号：81371919）；湖南省科学技术厅科技计划项目（编号：2012WK3039）；福建省医学创新课题（编号：2014-CXB-51） |
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| English Abstract: |
| 【Abstract】 Objectives: To investigate the effects of the asymmetrical loading on the rat vertebral bone structure of morphological parameters of trabecula bone. Methods: 40 SD rats were divided into 2 groups: bipedal rat group and tether-bipedal rat group. Bipedal rat model was made by amputation of the forelimbs and tail. The left inferior angle of scapula to the ipsilateral bony pelvis was sutured in tether-bipedal rat group after amputation of the forelimbs and tail. After 8 weeks, the tethering suture was released. Spinal deformity was documented by serial X-ray examinations at an interval of 4 weeks. After sacrifice, the rotation angle of apical vertebra was measured and Micro CT was used to analyze the bone micro-architecture. Results: All rats in tether-bipedal rat group developed scoliosis and no scoliosis was detected in bipedal rat group. The average initial Cobb angle was 0° immediately after the operation and progressed to an average of 23.5°±4.2°(16°-31°) after 4 weeks, 40.6°±9.4°(28°－63°) after 8 weeks, 37.8°±9.9°(26°－50°) after 12 weeks. The average rotation angle of apical vertebra was 6.0°±2.2°(3.5°-9.0°). There was no difference in vBMD, BV/TV, Tb.Th, Tb.N or Tb.Sp between both sides of vertebra in bipedal rat group. The vBMD, BV/TV and Tb.Th on the concave side significantly increased, and Tb.Sp significantly decreased compared with that on the convex side in tether-bipedal rat group. The vBMD, BV/TV and Tb.Th on the concave side and vBMD on the convex side in tether-bipedal rat group significantly increased compared with those of the bipedal rat group. Conclusions: Suturing the left inferior angle of scapula to the ipslateral bony pelvis in bipedal rats can establish the scoliosis model successfully. Bone micro-architecture on the concave side of apical vertebra is remodeling, which can help to prevent the progress of scoliosis. |
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