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| ZENG Jiaxing,LIANG Bin,YIN Dong.MMP-3, IgG and CD68 expressions in the herniated nuclea pulposus between young and elder patients[J].Chinese Journal of Spine and Spinal Cord,2013,(12):1109-1115. |
| MMP-3, IgG and CD68 expressions in the herniated nuclea pulposus between young and elder patients |
| Received:January 04, 2013 Revised:July 08, 2013 |
| English Keywords:Lumbar intervertebral disc herniation MMP-3 IgG CD68 Adolescent Elderly |
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| English Abstract: |
| 【Abstract】 Objectives: To compare the expressions of cytokines MMP-3(matrix metalloproteinases, MMPs), IgG and CD68 in the herniated nuclea pulposus between young and elder patients, and to explore the pathogenesis of lumbar intervertebral disc herniation in the both aged patients. Methods: Disc samples from 40 patients with lumbar intervertebral disc herniation were collected. The patients were grouped as the young group, including 18 patients, with an avereage age of 20.6±3.4 years; the elder group, 22 patients, with the avereage age of 48.0±10.3 years. Disc degeneration was detected by HE staing. The expressions of MMP-3, IgG and CD68 was detected by immunohistochemistry. Then data were collected and measured by optical microscope. Results: Discs in the elder group showed degeneration by HE staing, the opposite for the young group, even no degenerative change was noted. There were less expressions of MMP-3 in young group(33.33%) than elder group(81.82%), more expressions of IgG in young group(66.67%) than elder group(31.82%), and more expressions of CD68 in young group(83.33%) than elder group(45.45%). Positive expressions of MMP-3, IgG and CD68 in two groups were different. Conclusions: Immunative and inflammative reaction maybe the main mechanism inducing disc herniation in the young, while in the elderly, disc degeneration maybe the main cause. |
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