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| CAO Yong,YAO Yu,ZHANG Feng.Correlation of lumbar disc herniation with the Th17 cells, NK cells[J].Chinese Journal of Spine and Spinal Cord,2013,(10):912-915. |
| Correlation of lumbar disc herniation with the Th17 cells, NK cells |
| Received:December 26, 2012 Revised:June 08, 2013 |
| English Keywords:Lumbar disc herniation Th17 cells NK cells, Cytokine IL-17 Flow cytometry |
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| English Abstract: |
| 【Abstract】 Objectives: To explore the role of T help cells 17(Th17), natural killer cells(NK) in the development of sciatica and the pathological mechanism of nerve root pain. Methods: 20 postoperative patients with lumbar disc herniation and treated in the Spine Centre of Nan Tong University Affiliated Hospital were included as observation group. Control group included 6 patients with lumbar fracture in the same hospital. Flow cytometry (Flow Cytometry, FCM) was used to measure the expression of CD3, CD4, T cell intracellular product Th17 and NK cell surface factor CD16CD56 content in each group. Results: The CD4, IL-17 and CD16CD56 content in nucleus pulposus of observation group was (3.18±0.15)%, (2.94±0.04)%, (3.24±1.65)% respectively with hi expression; while in control group, it was (0.08±0.02)%, 0%, (1.73±0.71)% respectively, with lower expression or no expression(P=0.000, 0.000, 0.003). The expression of CD3 in observation group and control group was (23.42±5.84)% and (26.54±4.17)%, the difference was no statistically significant(P＞0.05). Conclusions: When exposed in the immune system, the Th cells on the surface of the nucleus pulpous may differentiate into Th17 cells, and induce the expression of NK cells with surface mark of CD16CD56. |
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