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| GUO Jiayong,YIN Zongsheng,WANG Wei.The spinal fusion results between calcium phosphate ceramics and autologous iliac, a meta-analysis[J].Chinese Journal of Spine and Spinal Cord,2013,(4):335-340. |
| The spinal fusion results between calcium phosphate ceramics and autologous iliac, a meta-analysis |
| Received:December 03, 2012 Revised:January 25, 2013 |
| English Keywords:Spinal fusion Calcium phosphates Autograft Meta-analysis |
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| English Abstract: |
| 【Abstract】 Objectives: To evaluate the efficacy of calcium phosphate ceramics versus autograft on spinal fusion. Methods: Randomized controlled trials related to application of calcium phosphate ceramics in spinal fusion versus autograft were searched on Pubmed, Embase, ScienceDirect, OVID, Springer Link, Wiley Online Library, Chinese biomedical database(CBM), Chinese National Knowledge Infrastructure(CNKI) and Wan fang database from January 1990 to October 2012. Some relevant journals were hand-searched as well． Two reviewers independently evaluated the quality of the included studies and extracted the data. Meta-analysis was performed by STATA 12.0 software. Results: Eight randomized controlled trials involving 388 patients were included. The exact number of participants was reported in seven trials, including a total of 357 patients. 178 patients underwent allograft with calcium phosphate ceramics, and 179 patients with autograft. The combined results showed no statistically significant difference in the fusion rate between the two groups[RR=0.975, 95%CI(0.887, 1.073); RD=-0.009, 95%CI(-0.048, 0.031)]. Six eligible studies recorded the number of fused levels, that 217 levels underwent allograft with calcium phosphate ceramics and 205 levels with autograft. No significant difference was identified between the two groups[RR=0.979, 95%CI(0.903, 1.061); RD=-0.009, 95%CI(-0.043, 0.026)]. Conclusion: Both calcium phosphate ceramics and autograft are effective for spinal fusion. Calcium phosphate ceramics is a favorable alternative to autograft. |
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