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| ZHANG Jiye,WANG Jixing,ZHANG Bin.Ｔhe experimental ｓtudy on osteoarthritis of the lumbar facet joints in rabbits induced by high stress[J].Chinese Journal of Spine and Spinal Cord,2011,(10):853-859. |
| Ｔhe experimental ｓtudy on osteoarthritis of the lumbar facet joints in rabbits induced by high stress |
| Received:April 07, 2011 Revised:July 05, 2011 |
| English Keywords:Facet joints Stress Degeneration Osteoarthritis Cytokine |
| Fund:基金项目：广东省自然科学基金资助项目（9151051501000027）；南方医科大学南方医院院长基金资助项目（2008B009） |
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| English Abstract: |
| 【Abstract】 Objective：To investigate the pathological changes and associated mechanisms of degenerative lumbar facet joints in rabbits caused by experimental stress.Methods：Forty-two New Zealand white rabbits were randomly divided into 4 groups（A，B，C，D） which were assigned into different treatments.Group A received sham operation with intact lumbar spine structures.In Group B，nucleus pulposus was aspirated to produce disc degeneration.In Group C，springs were put on the adjacent facets of L3/4 and L5/6 to stress the facet joints. Group D received the treatments on both B and C group.Facet joints were harvested after 4 and 8 months respectively.Sections of facet joint were stained with Safranin O-fast green,and the severity of cartilage degeneration was determined according to the Mankin score.The expressions of IL-1β，IL-6 ａｎｄ TNF-α in facet joint cartilage were detected with immunohistology.Results：The severity of facet joint degeneration was significantly different among different groups（F=92.77，P＝0.000）.In each group，facet joint degeneration at the 8th month was more severe than that at the 4th month（P＜0.05）.Facet joints between Group A and B or Group C and D did not show significantly treatment-associated difference（P＞0.05）.While facet joint degeneration in groups C and D，which loaded additional stress in facet joints，was more severe than that in groups A and B（P＜0.05）.The expression intensity of cytokines in degenerative cartilage has significantly increased with the severity of cartilage degeneration.But the expression intensity of cytokines has significantly decreased in severe degeneration.Conclusions：High stress on facet joints induced lumbar facet joint degeneration.The longer the stress，the more severe degeneration on lumbar facet joint.Cartilage degeneration of lumbar facet joint associated with the changes of inflammatory cytokine synthesis and secretion. |
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