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| YUAN Shuo,QIU Yong,ZHU Feng.The bone mineral density in adolescents with neurofibromatosis 1 scoliosis[J].Chinese Journal of Spine and Spinal Cord,2011,(4):280-284. |
| The bone mineral density in adolescents with neurofibromatosis 1 scoliosis |
| Received:November 16, 2010 Revised:December 04, 2010 |
| English Keywords:Neurofibromatosis 1 Scoliosis Adolescent Bone mineral density |
| Fund:基金项目：江苏省自然科学基金项目（编号：BK2010109） |
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| English Abstract: |
| 【Abstract】 Objective：To evaluate the bone mineral density（BMD） in adolescents with scoliosis secondary to neurofibromatosis 1（NF1） and the relationship between BMD and severity and type of scoliosis．Method：From March 2008 to April 2010，23 adolescents suffering NF1 scoliosis were reviewed retrospectively.All cases were divided into 2 groups based on abnormality，14 patients（group A） with dystrophic thoracic scoliosis had the mean age of 13.4 years（range，10 to 18 years） and mean Cobb angle of 84.1°（range，60° to 132°），while 9 patients（group B） with non-dystrophic thoracic scoliosis had the mean age of 13.2 years（range，11 to 16 years） and mean Cobb angle of 71.4°（range，40° to 87°）．Meanwhile，24 volunteers with the mean age of 14.7 years（range，l0 to 17 years） were selected as control（group C）．The BMD of the lumbar spine（L2-L4） and the proximal femur was measured using dual energy X-ray absorptiometry in all cases．BMD was compared among three groups by one-way ANOVA analysis.The relationship between BMD and Cobb angle within group A and group B was assessed using Pearson correlation analysis.Result：No differences in terms of age and sex ratio were noted in three groups（P>0.05）．The Cobb angle and the BMD of the lumbar spine and the proximal femur in group A showed no significant differences compared with group B（P>0.05）．However，both groups A and B showed significant lower BMD than group C（P<0.05），and the diminution of BMD in lumbar spine was more remarkable than that in proximal femur．The values of BMD in group A and B showed no relationship with Cobb angle.Conclusion：The decreased BMD exists in adolescents with dystrophic or non-dystrophic scoliosis secondary to NF1.However，the BMD is not correlative with the type or the severity of scoliosis. |
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