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| LIU Zhen,QIU Yong,CAO Xingbing.[J].Chinese Journal of Spine and Spinal Cord,2010,20(1):57-61. |
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| Received:December 10, 2008 Revised:October 09, 2009 |
| English Keywords:Adolescent idiopathic scoliosis Leptin gene Gene polymorphism Genotype Female |
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| English Abstract: |
| 【Abstract】 Objective：To investigate the association of -2548G/A（rs7799039） functional polymorphism in the promoter region of leptin gene with abnormal growth pattern in girls with adolescent idiopathic scoliosis（AIS）.Method：Blood samples were obtained from 451 female AIS patients and 335 female healthy adolescents.Anthropometric parameters of AIS group including age，body height，weight，Cobb angle，time of menarche and Risser sign were recorded.Polymerase chain reaction-restriction fragment length polymorphism（PCR-RFLP） technique was used to detect and analyze leptin gene distribution in AIS group and control group.The anthropometric data（body height，BMI，time of menarche and Risser sign），Cobb angle and genotypes of leptin gene polymorphism for AIS patients and normal subjects were also compared.Result：The genotype and allele frequency distribution were comparable between AIS and normal control.There was no association with curve severity，body height，time of menarche，Risser sign and BMI in AIS patients.Between the AIS patients grouped according to the curve pattern and the controls，there was no difference on the distribution of rs7799039 site polymorphism.Conclusion：-2548G/A functional polymorphism in the promoter region of leptin gene is neither associated with the occurrence or the curve severity of AIS girls nor different curve pattern groups of the AIS. |
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