| 潘福敏,王善金,麻 彬,亓东铎,巴兆玉,黄宇峰,赵卫东,吴德升.Ⅱ型糖尿病与腰椎间盘退变的相关性[J].中国脊柱脊髓杂志,2015,(12):1079-1082. |
| Ⅱ型糖尿病与腰椎间盘退变的相关性 |
| 中文关键词: 腰椎间盘退变 Ⅱ型糖尿病 磁共振 Pfirrmann分级 |
| 中文摘要: |
| 【摘要】 目的：探讨Ⅱ型糖尿病（DM）与腰椎间盘退变的相关性。方法：选择2013年因腰腿痛至我院脊柱外科门诊就诊并满足入选标准的390例50~60岁患者，详细记录患者DM病史，其中非DM患者123例（非DM组）、血糖控制较好患者140例（A组），血糖控制较差DM患者127例（B组）；A组中DM≤10年68例（A1组），DM＞10年72例（A2组）；B组中DM≤10年60例（B1组），DM＞10年67例（B2组）。用Pfirrmann评分系统对各组患者各节段腰椎间盘退变程度进行评分，用SPSS 19.0统计分析DM与腰椎间盘退变程度的相关性。结果：各组资料均服从正态分布（P＞0.05）。各组间一般资料无显著性差异（P>0.05）。在L1/2~L5/S1每节段上，A1组Pfirrmann评分与非DM组无显著性差异（P＞0.05）；A2、B1及B2组的Pfirrmann评分显著高于非DM组（P＜0.05）。A2、B2组Pfirrmann评分显著较A1、B1组高（P＜0.05）；B1、B2组Pfirrmann评分均较A1、A2组高（P＜0.05）。在A、B组中，L1/2~L5/S1每一节段上腰椎间盘退变程度与DM病程呈显著性正相关（P＜0.05）。结论：DM＞10年及血糖控制不良是腰椎间盘退变的危险因素，腰椎间盘退变程度与DM病程呈正相关。 |
The relationship between type Ⅱ diabetes mellitus and lumbar disc degeneration |
| 英文关键词:Lumbar discs degeneration Diabetes mellitus Type Ⅱ Magnetic resonance imaging Pfirrmann grading system |
| 英文摘要: |
| 【Abstract】 Objectives: To observe the relationship between type Ⅱ diabetes mellitus(DM) and lumbar discs degeneration(LDD). Methods: During 2013, 390 adults with low back pain in our spine clinic were chosen according to the including criterion. All the patients were divided into the following three groups: non-DM group(n=123), well-controlled DM group(group A; n=140) and badly-controlled DM group(group B; n=127). In group A, 68 patients were with DM duration ≤10 years(group A1), and 72 patients with DM duration ＞10 years(group A2); in group B, there were 60 patients with DM duration ≤10 years(group B1) and 67 patients with DM duration ＞10 years(group B2). Severity of LDD was evaluated by the five-level Pfirrmann grading system. SPSS 19.0 was used to analyze the relationship between type Ⅱ DM and LDD. Results: The data of each group obeying the normal distribution(P＞0.05) and demographic data showed no different between two groups(P＞0.05). From L1/2 to L5/S1, the average Pfirrmann scores between group A1 and non-DM patients showed no difference(P＞0.05); group A2, B1 and B2 showed higher average Pfirrmann scores than non-DM patients(P＜0.05). Group A2 and B2 showed higher average Pfirrmann scores than group A1 and B1(P＜0.05). Group B1 and B2 showed higher average Pfirrmann scores than group A1 and A2(P＜0.05). From L1/2 to L5/S1, the severity of LDD was highly related to DM duration both in group A and B(P＜0.05). Conclusions: DM duration ＞10 years and bad control of DM are the risk factors of LDD, and severity of LDD is highly related to DM duration. |
| 投稿时间：2015-05-26 修订日期：2015-10-29 |
| DOI： |
| 基金项目:国家自然科学基金青年基金资助项目（编号：81201418）；同济大学青年优秀人才培养行动计划资助项目（编号：2013KJ075）；浦东新区卫生系统重点学科建设资助项目（编号：PWZx2014-02） |
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