| 徐鸿明,胡 斐,王雍立,金海明,陶周善,王向阳.兔椎体软骨终板内血管三维影像结构研究[J].中国脊柱脊髓杂志,2015,(11):1013-1017. |
| 兔椎体软骨终板内血管三维影像结构研究 |
| 中文关键词: 椎体终板 血管 血管造影 硫酸钡 Micro-CT 兔 |
| 中文摘要: |
| 【摘要】 目的：研究兔椎体软骨终板内血管的三维影像结构。方法：选取6月龄日本大耳白兔（2.5~3kg）5只，使用Micro-CT对通过腹主动脉注射硫酸钡造影剂后的兔L4、L5椎体及其终板进行10mm与5mm范围扫描，将扫描结果导入Mimics软件进行血管三维结构重建，观察椎体终板内血管的三维结构。10mm与5mm范围扫描结果分别为10mm组和5mm组，从两组血管三维图中随机选取5个血管末端并测量其直径大小。结果：Mimics软件重建的椎体终板内血管三维结构清晰可见。10mm组终板内血管俯视图可见血管在终板内接触髓核部分的中心区域分布密集，管径粗，并向四周的接触纤维环部分的终板呈放射状辐射；矢状面上可见终板将椎体部分与椎间盘内纤维环及髓核部分明显分隔开，其内血管从椎体后方发出，沿终板后方向前方辐射长入。5mm组图像可见终板内接触髓核部分的中心区域的血管与接触纤维环部分的外周区域的血管结构不同，接触纤维环部分的外周区域的血管形状为单一襻样结构，而终板内接触髓核部分的中心区域的血管是一种复杂的完全缠绕在一起的血管襻结构。5mm组血管末端直径明显小于10mm组血管末端直径（P<0.001）。结论：注射硫酸钡造影剂后用Micro-CT扫描建立终板内血管三维结构的方法可以清楚地显示兔终板内血管的三维结构，为进一步研究终板血管变化提供新的技术手段。 |
3D structural study of vessels in rabbit′s intervertebral endplate |
| 英文关键词:Intervertebral endplate Vessels Angiography Barium sulfate Micro-CT Rabbit |
| 英文摘要: |
| 【Abstract】 Objectives: To observe the 3D structure of the vessels in rabbit′s endplate by injecting barium sulfate contrast agent and reconstructing the 3D structure. Methods: Five 6-month-old rabbits(2.5-3kg) were used in this study. The rabbit′s endplate(L4, L5) was scanned by micro-CT which was injected with barium sulfate contrast agent in the abdominal aorta, and then the scanned data were imported into the Mimics Software for 3D reconstruction of the vascular structure in the rabbit′s intervertebral endplate. Each sample needs to be scanned twice according to the size of the scan range(FOV: 10mm and 5mm). Then 5 blood vessels were randomly selected and the diameters were measured in each group. The data were divided into two subgroups(10mm and 5mm). Results: The 3D structure of the rabbit′s intervertebral endplate vessels was observed by Mimics software. In the top view of the 10mm group, the vessels were observed as dense distribution in the central portion(nucleus pulposar) with larger diameter and diverged to the lateral portion(inner anular). In the sagittal plane, the vertebral body and intervertebral disc were clearly separated, and the vessels emitted from the rear of the vertebral body and ingrowth along the endplate divergent. In the 5mm group, the vessels in the central portion(nucleus pulposar) exhibited swollen and complex coil-like loops, which were different with the vessels in the lateral portion(inner anular) formed simple loops. The diameter of vessels in the 5mm group was significantly smaller than that in the 10mm group(P<0.001). Conclusions: Our study suggests that the blood vessels in rabbit endplate can be clearly observed by the method described, which can provide a new technique for the further study of the intervertebral endplate vessels. |
| 投稿时间：2015-06-26 修订日期：2015-10-04 |
| DOI： |
| 基金项目:国家自然科学基金项目（编号：81371988）；浙江省自然科学基金项目（编号：LR12H06001）；浙江省医药卫生重大科技计划（编号：WKJ-ZJ-1527） |
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